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Since prazosin is highly bound to plasma proteins, the possibility that it may interact with other highly protein-bound drugs should be considered. 6585

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Beta- adrenergic blockers may also potentiate the postural hypotensive effect of the first dose of prazosin, probably by preventing reflex tachycardia. 5777

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In the studies reported to date, the overall incidence of side-effects and the proportion necessitating withdrawal of therapy have been similar with both drugs when studied under the controlled conditions of therapeutic trials, but the nature of side-effects differ; tiredness is more common with methyldopa and although dizziness is more

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Each tablet contains 1 mg, 2 mg or 5 mg of prazosin as the active ingredient. 3306

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